Khaberni - A major scientific study published in the medical journal "The Lancet" warned that some common antidepressants could increase the risks of obesity and heart problems.
The study, conducted by researchers at King’s College London on more than 58,000 patients, compared 30 types of antidepressants and found noticeable differences in their physical effects, especially on cardiovascular health.
According to the results, amitriptyline, one of the oldest and most prescribed antidepressants, was one of the most concerning drugs. About half of the patients gained extra weight after just a few weeks of use, with an increase of nearly 1.5 kg in just eight weeks. A clear rise in heart rate and blood pressure was also observed, increasing the risks of heart disease, stroke, and early death.
The study showed that every 1 kilogram increase in weight could raise the risk of heart disease by 3%, while the heart rate for users of the drug nortriptyline increased by more than 13 beats per minute.
The researchers also pointed out that other drugs, including mirtazapine and a group of tricyclic antidepressants, were associated with a significant increase in weight, while there was a slight decrease in weight for users of some newer drugs like citalopram.
The study team recommended updating official medical guidelines, assessing the patient's health history before choosing a medication, and conducting regular physical examinations for depression patients under treatment.
Dr. Tony Bellinger, the lead researcher, affirmed that "antidepressants are not identical," warning of the rapid changes that can occur in weight and blood pressure over a short period.
On the other hand, other experts have called not to abruptly stop treatment, affirming that the study does not negate the confirmed benefits of these drugs on mental health, and that their risks vary from person to person.
These warnings come at a time when figures indicate that 8.8 million people in England are taking antidepressants, roughly one out of every seven people, with an increase in prescriptions annually, where more than 92 million prescriptions were dispensed during the year 2024-2025.
As concerns about the long-term cumulative effects rise, doctors suggest a "collaborative" therapeutic approach between the doctor and the patient, to ensure the selection of the right medication and minimize complications.
The study concludes with a clear emphasis that "the goal is not to frighten, but to empower patients to make an informed decision and to provide safer, more personalized care."
Doctors advise patients who notice side effects to speak with specialists before making any decisions, especially stopping the medication, with the possibility of adjusting the dose or replacing the treatment.
