Khaberni - An international research team revealed an innovative vaccine capable of preventing serious immune reactions and inflammations that could threaten the lives of mice, opening new possibilities for treating severe allergies in humans in the future.
The study, co-led by Nobel laureate Drew Weissman, demonstrated that the vaccine, which uses mRNA technology, prevents allergens from triggering deadly immune responses, described as "a major scientific breakthrough for millions of people around the world suffering from severe allergies."
Traditional vaccine production methods rely on cultivating viruses or their proteins inside animal cells and then purifying them, a complex and lengthy process. In contrast, mRNA vaccines use ribonucleic acid molecules that send instructions to the body to produce specific proteins that fight disease agents, turning the body into a natural vaccine factory.
The study showed that this technology is not limited to preventing infectious diseases but can also be used to treat chronic immune diseases, such as allergies.
Study details
The researchers modified mRNA molecules to instruct mouse cells to produce proteins that resemble some allergens, allowing the immune system to recognize and deal with them orderly.
The results showed that the vaccinated mice did not exhibit any allergic reaction, also recording a significant decrease in the number of white blood cells associated with allergies, reduced inflammation protein production, and decreased mucus secretion in the lungs.
The vaccine also prevented airway constriction, a phenomenon that usually occurs during asthma attacks, alongside stimulating the production of special antibodies that protect against allergic reactions in the future.
The researchers hope that the mRNA vaccine will offer a more flexible solution compared to traditional allergy treatments, which require repeated doses over months or years.
Since mRNA molecules can be modified to produce proteins against various types of allergens, the team believes this technology can be applied to a wide range of conditions, including seasonal allergies to dust and dust mites, food allergies, and asthma.
Broader Prospects for mRNA Technology
The study indicates that mRNA vaccines are not limited to preventing infectious diseases like "COVID-19," but can also extend to treating chronic immune diseases like Celiac disease.
Weissman said: "We have witnessed the role of mRNA vaccines in saving lives during the pandemic, and as they are among the most tested types of vaccines in the history of medicine, we are confident they are the safest and most effective so far. We are fully committed to continuing to explore the possibilities of this technology."
The study was published in the Journal of Clinical Medicine Research.
