Khaberni - The journal Analytica Chimica Acta, one of the world's leading journals in analytical chemistry, has published a scientific study by the Jordanian doctor Mona Mustafa Sharar, who during it developed an innovative analytical method that allows the measurement of the bioavailability of oral drugs directly inside cells with high accuracy.
The research aims to study the ability of drugs to cross the cell wall, contributing to the development of more effective oral medications for cancer patients as an alternative to intravenous injections.
The study presented an advanced laboratory model that was tested on human cancer cell lines (HeLa) and kidney cell lines (MDCKII), where the results showed a significant match with the results of traditional animal experiments in evaluating drug absorption after passing through the intestinal and liver walls. The new method provides a precise and reliable tool for understanding how drugs reach targeted cells.
The study gains special importance given the traditional reliance on animal experiments to evaluate the bioavailability of drugs, which are high-cost experiments that raise ethical challenges. The new methodology contributes to accelerating the early stages of pharmaceutical research and developing more effective treatments, while reducing the need for animal models used in drug testing.
The research was chosen to be presented at the conference of the American Society for Mass Spectrometry (ASMS), which was held in the city of San Diego in 2026.
Dr. Sharar graduated from Jordan University of Science and Technology and the University of Jordan, before obtaining her PhD in Analytical Chemistry and Life Sciences from Humboldt University in Berlin through a competitive scholarship.
