Khaberni - A study published by the Journal of Personalized Medicine found a link between the severity of chronic kidney disease (CKD) and an increased risk of gastroparesis (gastroparesis).
Dr. Ziaoling Wang from the Cleveland Clinic Hospital and his colleagues conducted a retrospective population-based analysis, which included inpatient and outpatient data, to examine the relationship between chronic kidney disease and gastroparesis.
Data from 3,579,372 patients diagnosed with gastroparesis, with or without chronic kidney disease, from the national inpatient sample, and 6,263,251 outpatient patients who presented with nausea and vomiting from the TriNetX database, were included.
The researchers observed an increase in the prevalence of gastroparesis that correlated with the severity of chronic kidney disease in the inpatient group, with the highest probability appearing in the advanced stages compared to patients who do not suffer from chronic kidney disease.
The chronic kidney disease group of outpatient patients also showed an increased risk of gastroparesis, while the severity dependence pattern was not consistent.
After conducting strict matching for propensity scores - a statistical method used in observational (non-experimental) studies to simulate randomized trial conditions - there remained a significant association between advanced chronic kidney disease and increased likelihood of gastroparesis, with the highest risk observed in patients with end-stage renal failure.
The authors wrote: "These findings suggest that gastroparesis may be an underrecognized comorbid condition in chronic kidney disease, especially in advanced stages, where delayed gastric emptying can lead to further deterioration of nutritional status, increased symptom burden, and negatively impact the overall prognosis of the disease course.""
