Khaberni - Despite the striking results achieved by modern weight loss medications such as Ozempic, Mounjaro, and Wegovy, they do not represent a final solution on their own, as medical research reveals that maintaining weight after stopping them remains the biggest challenge for many users.
Studies published in specialized endocrinology and obesity journals, including scientific reviews in The New England Journal of Medicine and The Lancet Diabetes & Endocrinology, indicate that GLP-1 drugs can increase weight loss by up to four times compared to individual attempts, but could be linked to weight regain if not accompanied by a clear therapeutic and behavioral plan.
Dr. Donald Grant, the chief clinical consultant at The Independent Pharmacy, warns that sudden cessation of these medications leads to a significant increase in appetite, as a result of the loss of the hunger-regulating hormone’s effect, which prompts some to quickly regain weight. Medical literature confirms that gradual discontinuation, under medical supervision, reduces this relapse.
Studies agree that the absence of lifestyle changes is the primary reason for the failure of long-term results. Even with pharmaceutical treatment, commitment to a balanced diet and regular physical activity remain essential elements for weight stability, supported by the recommendations of the American Endocrine Society.
Research clarifies that early discontinuation before completing the recommended treatment duration, which may range from 12 to 24 months, reduces the body's metabolic adaptation to the new weight. Furthermore, neglecting to adjust the diet during and after treatment, particularly regarding protein and fiber, increases the risk of losing muscle mass and slowing metabolism.
Psychological studies published in Obesity Reviews highlight that the emotional relationship with food, such as eating related to stress or sleep disorders, plays a crucial role in weight regain, making behavioral and psychological support an integral part of the treatment.
Specialists affirm that regular weight monitoring and consuming adequate amounts of protein to maintain muscles are important preventive tools after stopping GLP-1 medications, to ensure that the weight loss journey does not become a closed loop of ups and downs.
