Khaberni - Scientists achieved a massive medical breakthrough, finding a method that rejuvenates and eliminates aging, successfully tested on mice. This discovery opens the door to soon testing it on humans, potentially leading to a treatment that combats aging and keeps youthful freshness.
As we age, the productivity of blood-forming stem cells decreases, impacting the immune system and increasing the risk of diseases such as anemia and cancer.
A report published by the scientific site "Science Alert" and reviewed by "Alarabiya.net," stated that scientists discovered a method to restore blood-producing stem cells to their normal state, which could help treat blood deficiency and age-related immune deficiencies.
The scientists explained that "excited stem cells," like most human cells, contain tiny parts known as lysosomes, which are cell recycling centers. Complex molecules, such as proteins and fats, are sent there to be broken down into smaller, reusable pieces.
It turns out that many of the problems that arise in the excited blood-forming stem cells in the elderly are due to dysfunction in the lysosomes, according to a new study conducted by researchers from the Icahn School of Medicine at Mount Sinai Hospital in the United States and the University of Paris City.
Saghi Ghaffari, a stem cell biologist, conducted experiments on mice. He found that the lysosomes in the blood-forming stem cells of older mice were characterized by high acidity and clear dysfunction. The blood-forming stem cells taken from older mice also exhibited excessive activity. This overactivity is contrary to the behavior of young blood-forming stem cells, which are characterized by their dormancy, providing them stability and longevity.
Ghaffari and his team succeeded in "calming" the tired and elderly lysosomes in the old blood-forming stem cells using a chemical called Concanamycin A. This substance returned their acidity and activity levels to normal.
After removing the blood-forming stem cells from the mice and treating them with the chemical before returning them, the tissue's ability to produce new blood cells increased eightfold.
With the stabilization of the lysosomes, the old stem cells began to act more youthfully. Their ability to regenerate improved, and they resumed producing blood cells in appropriate ratios. This reversed the old blood-forming stem cells' tendency to reduce the efficiency of the immune system by producing certain cells more than others.
Ghaffari said: "Our results reveal that aging in blood-forming stem cells is not an irreversible fate. The old blood-forming stem cells have the ability to return to a youthful state, and they can revert to their normal condition."
Ghaffari added: "By slowing down the lysosomes and reducing their acidity, the stem cells became healthier, and were able to produce new, balanced blood cells and new stem cells much more effectively. By targeting hyperactivity of the lysosomes, we managed to reset the old stem cells to a more youthful and healthier state, which improved their ability to renew blood and immune cells."
