Khaberni - A large scientific study published in "The Lancet" medical journal warned that some common antidepressants may increase the risk of obesity and heart problems.
The study, conducted by researchers at King's College London on more than 58,000 patients, compared 30 types of antidepressants and found significant differences in their physical effects, particularly on cardiovascular health.
According to the results, amitriptyline, one of the oldest and most prescribed antidepressants, emerged as one of the most concerning drugs. About half of the patients gained significant weight after just a few weeks of its use, increasing by approximately 1.5 kg in just eight weeks. A clear increase in heart rate and blood pressure was also observed, increasing the risks of heart disease, stroke, and premature death.
The study showed that every 1 kilogram increase in weight might raise the risk of heart disease by 3%, while the heart rate for nortriptyline users increased by more than 13 beats per minute.
The researchers also noted that other drugs, including mirtazapine and a group of tricyclic antidepressants, were associated with a significant weight gain, whilst a slight decrease in weight was observed in users of some newer drugs such as citalopram.
The research team recommended updating the official medical guidelines, assessing the patient's health history before choosing the medication, and conducting regular physical examinations for patients with depression under treatment.
Dr. Toni Bellinger, the lead researcher, emphasized that "antidepressants are not identical," warning of rapid changes that might occur in weight and blood pressure within a short period.
In contrast, other experts called for not stopping the treatment abruptly, affirming that the study does not negate the confirmed benefits of these drugs on mental health, and that the risks vary from person to person.
These warnings come amid figures indicating that 8.8 million people in England are taking antidepressants, roughly one in every seven people, with prescription rates increasing annually, as more than 92 million prescriptions were issued during the year 2024-2025.
As concerns rise over the long-term cumulative effects, doctors call for a "collaborative" therapeutic approach between the doctor and the patient, to ensure the right medication choice and minimize complications.
The study concludes with a clear emphasis on "the goal not being to scare, but to empower patients to make informed decisions, and to provide safer, more personalized care."
Doctors advise patients who notice side effects to discuss with specialists before making any decision, especially stopping the medication, with the possibility of adjusting the dose or changing the treatment.
